Unlocking Selenium Chemical Space via a Programmable Synthesis Platform Bearing Cannabinoid Receptor Recognition Motifs
R. Of the new chemotypes discovered and synthesized, many compounds showed nanomolar to sub-nanomolar binding affinity for the CB1 receptor.
Authors
- Maloba M. M. Lobe (ORCID: https://orcid.org/0000-0002-5366-6936)
- Malliga R. Iyer (ORCID: https://orcid.org/0000-0002-0116-4619)
- Subhradeep Dutta
- Grzegorz Godlewski
- Henry L. Puhl (ORCID: https://orcid.org/0000-0003-3095-7201)
- Sergio A. Hassan (ORCID: https://orcid.org/0000-0003-3319-078X)
- Pinaki Bhattacharjee (ORCID: https://orcid.org/0000-0003-1818-3610)
- Paul Volesky
Institutions
- National Institutes of Health (US)
- National Institute on Alcohol Abuse and Alcoholism (US)
- National Institute of Allergy and Infectious Diseases (US)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2026-04-28
- DOI
- https://doi.org/10.1021/jacs.5c16359
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism