Association Between Polymorphisms rs11003125 and rs7096206 of the <i>MBL2</i> Gene and the Stages of Hepatitis B Progression in Burkina Faso: A Comparative Cross‐Sectional Study

Background and Objectives: Hepatitis B virus (HBV) infection remains a major global health burden, with disease progression influenced by host genetic and immune factors, including variants in the mannose-binding lectin 2 (MBL2) gene. This study aimed to evaluate the association between MBL2 polymorphisms and clinical outcomes of HBV infection in a cohort from Burkina Faso. Method: < 0.05 (Fisher's exact test). Results: = 0.01). Conclusion: From an exploratory perspective, the analysis of the rs11003125 and rs7096206 polymorphisms located in the promoter region of the MBL2 gene suggests their possible involvement in the progression of HBV infection. These preliminary results support the hypothesis of a potential functional role of this gene in HBV pathogenesis, while highlighting the need for further studies to confirm and clarify these associations.