Patients With Pancreatitis‐Related Gene Variants Showed Higher Incidence of Hyperpancreatic Enzymemia After Endoscopic Retrograde Cholangiopancreatography

Background: Post-endoscopic retrograde cholangiopancreatography (post-ERCP) pancreatitis (PEP) is the most severe adverse event associated with ERCP. Although numerous studies have identified risk factors for PEP, the role of genetic background in its development remains unexplored. The present study investigated the association between pancreatitis-related gene variants (PRG-variants) and PEP. Methods: . Patients were classified into two groups based on the presence or absence of PRG-variants, and the incidences of PEP and of post-ERCP hyperpancreatic enzymemia (PEH) were compared. Results: = 0.013) and multivariate analyses (odds ratio, 6.291; 95% confidence interval, 1.133-34.934). Conclusions: The present pilot study suggests that patients with PRG-variants, regardless of their pathogenicity, demonstrated a significantly higher incidence of PEH but not PEP. PEH may reflect pancreatic parenchyma injury and may progress to PEP when additional factors are present. Thus, PRG-variants may contribute to biochemical pancreatic injury after ERCP. Further large-scale studies and comprehensive genomic profiling of patients with PEH/PEP are warranted. Trial Registration: The central ethics committee approved the study protocol (M21-0066).