Development of a Predictive Flow Through Cell Dissolution Method for Carbamazepine Modified‐Release Tablets

prediction errors of -6.09% and -1.94%, respectively. The method effectively distinguished IR from MR formulations, with discriminatory analysis (f1, f2, DE, MDT) confirming its sensitivity. A predictive flow-through cell dissolution method was successfully developed, providing a robust tool for bioequivalence studies and generic formulation development. This approach supports formulation optimization and increases the likelihood of successful in vivo bioequivalence outcomes.