Balancing acceleration and turnover in [1 + 1] tetra-imine bis-calix[4]pyrrole reactor for Huisgen cycloadditions
) without direct quantification of the "Michaelis" ternary complex. Modest acceleration is observed for one pair of reactants, yet the cage can still turn over because the product is weakly bound. Extending the azide linker by one methylene dramatically enhances acceleration and introduces product inhibition. Comparisons with a related octa-imine cage reveal how subtle geometric changes tune the balance between transition-state stabilization and product release.
Authors
- Pablo Ballester (ORCID: https://orcid.org/0000-0001-8377-6610)
- Gemma Aragay (ORCID: https://orcid.org/0000-0002-2405-0278)
- Yifan Li (ORCID: https://orcid.org/0000-0001-8708-0004)
Institutions
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Institut Català d'Investigació Química (ES)
Publication Details
- Journal
- Nature Communications
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1038/s41467-026-72315-w
- Primary Topic
- Supramolecular Chemistry and Complexes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Centres de Recerca de Catalunya
- Generalitat de Catalunya
- Institut Català d'Investigació Química
- Agència de Gestió d'Ajuts Universitaris i de Recerca
- Agencia Estatal de Investigación