Faster and More Robust <scp>CK</scp> Reaction Rate Estimation at <scp>3T</scp> Using Acquisition‐Weighted <scp> ³¹ P </scp> Cardiac <scp>1D</scp> ‐ <scp>MRSI</scp> With Compartment‐Based Reconstruction

PURPOSE: ) in the human heart using phosphorus magnetic resonance spectroscopy is clinically important; however, it is limited by long acquisition times, operator subjectivity in analysis, and potential skeletal muscle contamination. This study evaluates if combining compartment-based reconstruction techniques with acquisition-weighted (AW) Triple Repetition Time Saturation Transfer (TRiST) acquisitions could overcome these challenges. METHODS: values were calculated and compared across reconstruction methods and acquisition types. RESULTS: , respectively. No significant differences were observed between FW and AW results. A significant decrease in cardiac PCr/ATP ratios was observed for SLAM and SLIM reconstructed data, suggesting decreased signal contamination from skeletal muscle. CONCLUSION: accuracy. This method provides a more robust and efficient evaluation of in vivo cardiac metabolism.