CD47 Blockade Reprograms the Monocyte-Macrophage Axis to Promote Inflammation Resolution in Atherosclerosis
macrophage population that natively harbors the efferocytosis machinery reactivated by therapy in mice. Together, these findings demonstrate that innate immune checkpoint inhibition by CD47 blockade drives a coordinated reprogramming of monocyte-macrophage dynamics, simultaneously suppressing inflammatory influx and enriching efferocytic capacity. This dual mechanism advances our understanding of how pro-efferocytic therapies resolve vascular inflammation in atherosclerosis.
Authors
- Mikael Ispirjan
- Norbert Frey (ORCID: https://orcid.org/0000-0001-7611-378X)
- Murat Kırtay (ORCID: https://orcid.org/0000-0001-5524-8220)
- Kai-Uwe Jarr (ORCID: https://orcid.org/0000-0003-3376-6478)
- Nicholas J. Leeper
- Lena Boehringer
- Moritz Miessler
- Anna-Lena Bruggner
- Benjamin Bonnard
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- German Centre for Cardiovascular Research (DE)
- Stanford University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-27
- DOI
- https://doi.org/10.64898/2026.04.24.720546
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00