Pulsed electromagnetic field drives osteogenic and suppresses adipogenic differentiation of bone marrow mesenchymal stem cells via Wnt/β-catenin signaling to ameliorate osteoporosis
co-administration of XAV-939 markedly attenuated these therapeutic benefits. Our findings establish that PEMF ameliorates osteoporosis by acting as a physical activator of the Wnt/β-catenin pathway in BMSCs, thereby rectifying their differentiation bias, and present a novel mechanism-based non-invasive strategy.
Authors
- Jian Wei (ORCID: https://orcid.org/0009-0001-5083-2046)
- Jiayue Xie
- Fang Xu
- Zhiyang He
Institutions
- Liuzhou General Hospital (CN)
- Fourth Affiliated Hospital of Guangxi Medical University (CN)
Publication Details
- Journal
- Bone Reports
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1016/j.bonr.2026.101920
- Primary Topic
- Electromagnetic Fields and Biological Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangxi Province