Two Novel Insulin-Sensitizing Peptides MGPR and AGPAGPR from <i>Miichthys miiuy</i> Fish Maw Alleviate Insulin Resistance Via Regulating the PPARγ-Driven IRS1/PI3K/AKT Signaling Pathway
-GSK3β, and downregulated p-IRS-1. In IR-HepG2 cells and diabetic zebrafish, these peptides improved glucose consumption and promoted lipid droplet formation. Thus, MGPR and AGPAGPR may serve as promising natural insulin sensitizers for IR-related glycemic control.
Authors
- Samad Tavakoli (ORCID: https://orcid.org/0000-0002-7205-1507)
- Siying Feng (ORCID: https://orcid.org/0000-0002-2685-4149)
- Luming Deng (ORCID: https://orcid.org/0000-0003-4804-2261)
- Jianwei Huang (ORCID: https://orcid.org/0000-0003-1974-8716)
- Menghua Wu (ORCID: https://orcid.org/0000-0003-0459-3723)
- Yuxiang Feng
- Yuzhen Zhu
- Xingyan Li (ORCID: https://orcid.org/0000-0002-7831-7169)
- Changchun Li
- Qianqian Ouyang
- Shengliang Yuan
- Kefeng Wu
Institutions
- Guangdong Medical College (CN)
- Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) (CN)
- Guangxi Mangrove Research Center (CN)
- Marine Biomedical Research Institute of Qingdao (CN)
Publication Details
- Journal
- Journal of Agricultural and Food Chemistry
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1021/acs.jafc.6c00728
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province