Pandemic SHV-106-producing Klebsiella pneumoniae ST231 isolated from Brazilian hedgehog (Coendou spinosus) reveals an emerging environmental circulation of a high-risk multidrug-resistant lineage
in an animal-derived K. pneumoniae ST231 in Brazil. The strain also harbored a class 1 integron and conjugative IncFIB and Col440I plasmids carrying multiple resistance genes, as well as heavy-metal tolerance operons, suggesting co-selection pressures in anthropized environments. The phylogenomic analysis demonstrated close clustering with globally distributed, predominantly human-derived ST231 genomes, indicating limited core-genome divergence. Collectively, these findings document the emergence of a high-risk MDR K. pneumoniae ST231 clone in Brazilian wildlife and highlight the role of wild animals as reservoirs and sentinels of clinically relevant AMR lineages, reinforcing the need for integrated One Health genomic surveillance at the human-animal-environment interface.
Authors
- Marcelo Meller Alievi (ORCID: https://orcid.org/0000-0002-4081-4362)
- Amanda Haisi (ORCID: https://orcid.org/0000-0002-0247-6905)
- Jéssica Amâncio Martins (ORCID: https://orcid.org/0000-0002-1845-9958)
- Natália C. Gaeta
- João P. Araújo Júnior
- Jacqueline Meyer
- Gustavo H. Z. Winter (ORCID: https://orcid.org/0000-0002-8327-444X)
- Marcos Bryan Heinemann (ORCID: https://orcid.org/0000-0001-6444-9788)
- Raquel F. S. Raimondo (ORCID: https://orcid.org/0000-0002-4013-7090)
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Universidade de São Paulo (BR)
- Hospital de Clínicas de Porto Alegre (BR)
- Fundação de Estudo e Pesquisa em Medicina Veterinária e Zootecnia (BR)
- Instituto de Conservação de Animais Silvestres (BR)
- Universidade de Santo Amaro (BR)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- Antonie van Leeuwenhoek
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1007/s10482-026-02317-7
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Division of Graduate Education