Kinetochore proteins control microtubule dynamics in postmitotic neurons to regulate the formation of dendritic spines
indicated that Ndc80, the microtubule-binding component of the kinetochore complex, slowed the rate of microtubule growth. The increase in spine number in mammalian neurons correlated with increased microtubule invasion of spines. Both spine number and microtubule invasion phenotypes induced by Ndc80 deletion could be rescued by reexpression of Ndc80, but only if the microtubule-binding region of NDC80 was preserved. We propose that kinetochore proteins act in a complex resembling the mitotic kinetochore in order to stabilize microtubule plus ends and thereby restrain spine invasions and the development of dendritic spines.
Authors
- Thomas L. Schwarz (ORCID: https://orcid.org/0000-0001-7532-0250)
- Leticia Peris (ORCID: https://orcid.org/0000-0002-0668-1252)
- Kang Shen (ORCID: https://orcid.org/0000-0003-4059-8249)
- Yves Goldberg (ORCID: https://orcid.org/0000-0001-7446-8595)
- Aditi Sharma (ORCID: https://orcid.org/0000-0001-7199-0361)
- Xing Liang (ORCID: https://orcid.org/0000-0003-4406-0753)
- Jing Tang (ORCID: https://orcid.org/0000-0003-2645-2032)
- Martina Aleman
- Feng Tian
- Zhigang He
- Jingqi Qi
- Lauren Miner
- Guoli Zhao (ORCID: https://orcid.org/0000-0002-7807-5980)
- Wangchu Xiang
Institutions
- Boston Children's Hospital (US)
- Harvard University (US)
- Inserm (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Grenoble Alpes (FR)
- Stanford University (US)
Publication Details
- Journal
- Proceedings of the National Academy of Sciences
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1073/pnas.2520684123
- Primary Topic
- Microtubule and mitosis dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Association France Alzheimer
- Fondation pour la Recherche sur Alzheimer
- National Institute of Neurological Disorders and Stroke