Carbamate and Sulfamate Bioisosteres of <i>N</i> , <i>N</i> ‐Dimethyl‐3β‐Hydroxycholenamide as Ligands of the Liver X Receptors
= 6.1). Molecular dynamics simulations of the LXRβ/ligand complexes confirmed a stable binding mode consistent with the dose-response data in all cases. The results set the foundation for developing novel analogues based on these compounds, particularly with sulfamate (3).
Authors
- Gerardo Burton (ORCID: https://orcid.org/0000-0002-8559-7306)
- María V. Dansey (ORCID: https://orcid.org/0000-0003-3611-6577)
- Rosana I. Misico (ORCID: https://orcid.org/0000-0001-7055-9721)
- Lautaro D. Álvarez (ORCID: https://orcid.org/0000-0001-8841-2330)
- Malena Pegenaute
- MF Martinez
- Facundo Perez
- Micaela B. Pugliese
- Florencia Di Salvo
Institutions
- Universidad de Buenos Aires (AR)
- Instituto de Química y Fisicoquímica Biológicas (AR)
- Fundación Ciencias Exactas y Naturales (AR)
Publication Details
- Journal
- ChemPlusChem
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1002/cplu.202600007
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agencia Nacional de Promoción Científica y Tecnológica