Reversing Cuproptosis Tolerance with Twinborn Metallic Polymer Nanoparticles for Enhancing Efficacy of Chemo-Immunotherapy
overload. In vivo studies of an orthotopic triple-negative breast cancer (TNBC) mouse model demonstrated the superior tumor suppression and immune activation of NP(Pt-Cu) over monotherapies. Overall, this work not only addresses cuproptosis tolerance via Wnt pathway inhibition but also provides a potent chemo-immunotherapeutic strategy for aggressive cancers.
Authors
- Jiang Zhao (ORCID: https://orcid.org/0000-0001-7788-2708)
- Minhui Cui
- Ganghao Liang
- Yi Zhou (ORCID: https://orcid.org/0000-0002-0273-007X)
- Hailong Zhang (ORCID: https://orcid.org/0000-0002-8951-7094)
- Li Zhang (ORCID: https://orcid.org/0000-0001-8142-403X)
- Haihua Xiao (ORCID: https://orcid.org/0000-0001-8159-8187)
Institutions
- Chinese Academy of Sciences (CN)
- Beijing National Laboratory for Molecular Sciences (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- ACS Nano
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1021/acsnano.6c02922
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China