Diazo-Preserving Radical Cascades for the Modular Photoinduced Synthesis of Oxindoles and Pyrazolones
) bond formation while preserving the diazo functionality. The method tolerates a broad range of functional groups, substitution patterns, and pharmaceutically relevant motifs. Mechanistic studies, including radical trapping, UV-vis spectroscopy, light on/off experiments, and Stern-Volmer analysis, support a radical chain propagation and distinguish the EDA-driven versus photoredox pathways. The resulting diazo heterocycles undergo downstream transformations to access new chiral centers and functional motifs.
Authors
- Albert Granados (ORCID: https://orcid.org/0000-0002-5362-5966)
- Carolina Gimbert‐Suriñach (ORCID: https://orcid.org/0000-0002-4412-7607)
- Adelina Vallribera (ORCID: https://orcid.org/0000-0002-6452-4589)
- Pau Sarró (ORCID: https://orcid.org/0000-0002-0957-2481)
- Roser Pleixats (ORCID: https://orcid.org/0000-0003-2544-732X)
Institutions
- Universitat Autònoma de Barcelona (ES)
- ORFEO-CINQA Research Network (ES)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1021/acs.orglett.6c01312
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerio de Ciencia, Innovación y Universidades
- Agència de Gestió d'Ajuts Universitaris i de Recerca