Concanavalin A targets phylogenetically conserved N-linked glycans on coronavirus spike proteins for broad-spectrum antiviral activity
. This work identifies conserved N-glycosylation sites on the spike protein as stable, vulnerable targets for antiviral intervention, distinct from the variable epitopes recognized by antibodies. These findings indicate that lectins like ConA may provide a promising approach for developing effective antivirals against emerging coronaviruses.
Authors
- Qiangyun Ai (ORCID: https://orcid.org/0000-0002-1028-4831)
- Xiancai Ma (ORCID: https://orcid.org/0000-0002-4934-4221)
- Yu Shi (ORCID: https://orcid.org/0000-0003-0651-4769)
- Hua Tao (ORCID: https://orcid.org/0009-0009-8987-0523)
- S Q Wang
- Dekuan Guo
- Qingxing Wang
- Geng Li (ORCID: https://orcid.org/0000-0001-9488-2128)
- Kaixiong Ma
- Huina Hu
- Sirui Han
Institutions
- Chinese Academy of Sciences (CN)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- Guangzhou Experimental Station (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Wuhan Institute of Virology (CN)
- Guangzhou Regenerative Medicine and Health Guangdong Laboratory (CN)
- University of Chinese Academy of Sciences (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Virology
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1128/jvi.01679-25
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00