The history and function of a circular RNA
Cdr1as/ciRS-7 is a circular RNA conserved in mammals and highly expressed in brain. It features a large number of microRNA target sites bound in vivo by miR-7/miR-671. Cdr1as regulates synaptic activity under stress in a temporal, spatial, and neuron-specific manner. We review genetic, molecular, evolutionary, and physiological data to discuss how Cdr1as and its interactors form a functionally important network of non-coding RNAs that regulates neuronal adaptability. We provide a framework to explore potential roles of other non-coding RNA networks on brain function and their diagnostic and therapeutic potential.
Authors
- Flavia Scoyni (ORCID: https://orcid.org/0000-0002-2764-7336)
- Grygoriy Zolotarov (ORCID: https://orcid.org/0000-0002-3971-3070)
- Jørgen Kjems (ORCID: https://orcid.org/0000-0003-4128-9317)
- Nikolaus Rajewsky (ORCID: https://orcid.org/0000-0002-4785-4332)
- Daniel León-Periñán (ORCID: https://orcid.org/0000-0002-7970-0362)
- Poojashree Bhaskar
- Cledi A. Cerda-Jara (ORCID: https://orcid.org/0000-0003-1783-5533)
Institutions
- Universitat Pompeu Fabra (ES)
- German Cancer Research Center (DE)
- Aarhus University (DK)
- Max Delbrück Center (DE)
- German Cancer Society (DE)
- National Center for Tumor Diseases (DE)
- German Centre for Cardiovascular Research (DE)
- Centre for Genomic Regulation (ES)
- Berliner Wasserbetriebe (Germany) (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Nature Communications
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1038/s41467-026-71822-0
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00