New Docking, Molecular Dynamics, and QSAR Models to Predict Disruption of Human and Rat Transthyretin Function by Per- and Polyfluoroalkyl Substances (PFAS)
levels, supporting the AOP. The development of reliable predictive toxicity models for PFAS requires extensive validation, maximal use of available experimental data, and careful consideration of toxicokinetic differences in interchemical comparisons.
Authors
- Heather M. Bolstad
- Sana Majid
- Angela K. Wilson (ORCID: https://orcid.org/0000-0001-9500-1628)
- Anatoly A. Soshilov
- Nuno M. S. Almeida (ORCID: https://orcid.org/0000-0002-6091-7289)
- Scott Coffin (ORCID: https://orcid.org/0000-0002-7035-1282)
Institutions
- California Environmental Protection Agency (US)
- Michigan State University (US)
Publication Details
- Journal
- Chemical Research in Toxicology
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1021/acs.chemrestox.5c00424
- Primary Topic
- Per- and polyfluoroalkyl substances research
- Type
- article
- Field-Weighted Citation Impact
- 0.00