The nuclear receptor ESRRA is a crucial regulator of acute kidney injury through inhibition of the lipophagy-ferroptosis axis
ACSL4: acyl-CoA synthetase long-chain family member 4; AKI: acute kidney injury; AKT/PKB: Akt serine/threonine kinase; ChIP: chromatin Immunoprecipitation; Cis-AKI: cisplatin-induced acute kidney injury; CI-AKI: contrast-induced acute kidney injury; ER: endoplasmic reticulum; ESRRA: estrogen related receptor, alpha; FFAs: free fatty acids; FA-AKI: folic acids-induced acute kidney injury; GPX4: glutathione peroxidase 4; GSH: glutathione; HK-2 cells: human renal proximal tubular epithelial cells; LDs: lipid droplets; LV: lentivirus; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MTOR: mechanistic target of rapamycin kinase; PPARGC1A/PGC1-α: PPARG coactivator 1 alpha; PIK3CA: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; PLIN2: perilipin 2; PNPLA2/ATGL: patatin-like phospholipase domain containing 2; PT: proximal tubular epithelial cells; PUFA: polyunsaturated fatty acid; RAB7: RAB7, member RAS oncogene family; ROS: reactive oxygen species; SQSTM1: sequestosome 1.
Authors
- S X Li (ORCID: https://orcid.org/0009-0000-6499-3556)
- Zhaohui Ni (ORCID: https://orcid.org/0000-0002-1334-7658)
- Haijiao Jin (ORCID: https://orcid.org/0000-0003-2804-4702)
- Xuying Zhu (ORCID: https://orcid.org/0000-0002-0037-9183)
- Shan Mou (ORCID: https://orcid.org/0000-0003-4160-1681)
- Chaojun Qi
- Zhenyuan Li (ORCID: https://orcid.org/0009-0005-0146-9235)
- Yuanting Yang (ORCID: https://orcid.org/0000-0001-7163-3436)
- Xinghua Shao
- Q N Lin
- Leyi Gu
- Jialin Li
- Yan Fang
Institutions
- Shanghai Jiao Tong University (CN)
Publication Details
- Journal
- Autophagy
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1080/15548627.2026.2665391
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation