A 60-year journey with a fungal transporter: from classical genetics to functional, structural, and evolutionary insights
transporters, including studies on cellular expression and turnover regulation. We additionally highlight up-to-date structural approaches that refined our knowledge on the transport mechanism, how substrate specificity is determined, and on membrane trafficking pathways underlying biogenesis and endocytosis of UapA and other transporters. The concepts developed through 60 years of persistent work on UapA have established important paradigms relevant to fungal physiology that have proven to be broadly applicable to understanding transporter-linked processes in other eukaryotic organisms.
Authors
- George Diallinas (ORCID: https://orcid.org/0000-0002-3426-726X)
- Claudio Scazzocchio (ORCID: https://orcid.org/0000-0001-8800-2534)
Institutions
- Centre National de la Recherche Scientifique (FR)
- National and Kapodistrian University of Athens (GR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- Institut de Biologie Intégrative de la Cellule (FR)
- CEA Paris-Saclay (FR)
- Institute of Molecular Biology and Biotechnology (BG)
- Imperial College London (GB)
Publication Details
- Journal
- Microbiology and Molecular Biology Reviews
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1128/mmbr.00364-25
- Primary Topic
- Fungal and yeast genetics research
- Type
- article
- Field-Weighted Citation Impact
- 0.00