Comparıson of Serum Adıpocyte Fatty Acıd Bındıng Proteın (A-Fabp) Levels in Predıabetıc Patıents and Healthy Indıvıduals

Prediabetes, a condition defined by the World Health Organization (WHO), has become a significant global health issue affecting a substantial portion of the world's population. This study aims to investigate the levels of adipocyte fatty acid-binding protein-4 (a-FABP or FABP-4), a biomarker found in individuals with prediabetes. FABP-4 is a protein released by both adipocytes and macrophages and plays a crucial role in influencing insulin resistance and lipid metabolism. The focus of this study is to evaluate FABP-4 levels in individuals with prediabetes and its correlation with metabolic parameters and CRP levels. The study was conducted on 90 participants, including individuals diagnosed with prediabetes (n= 44) and a healthy control (n= 44) group. The findings reveal that FABP-4 levels are significantly elevated in individuals with prediabetes. Furthermore, positive correlations were observed between FABP-4 levels and fasting and postprandial blood glucose, HbA1c and C-reactive protein (CRP). Regression analysis indicates that FABP-4 is an independently associated with prediabetes and, when considered alongside the triglyceride-to-high-density lipoprotein (HDL) ratio, is associated with prediabetes. This study underscores the association between FABP-4 and prediabetes, highlighting its potential role in fundamental processes such as insulin resistance, lipolysis, and inflammation. Additionally, it suggests that the triglyceride/HDL ratio is significantly associated with prediabetes. In conclusion, FABP-4 and the triglyceride/HDL ratio have the potential to be utilized as biomarkers in the assessment of prediabetes, contributing to the development of new treatment targets in this context.