<i>LncTUG1</i> Regulates miR-181a/ <i>BPIFB4</i> Axis to Promote COPD Inflammation

BACKGROUND: in COPD inflammatory processes. METHODS: , and miR-181a were detected by qPCR and western blot. Bioinformatic prediction and dual luciferase assays were used to predict the targeting relationship. Flow cytometry and ELISA assays evaluated the content of macrophages and inflammatory cytokines, respectively. RESULTS: 1 showed the opposite effects. CONCLUSIONS: promotes macrophage polarization toward the M2 type, thereby alleviating the inflammatory response in COPD. These findings provide theoretical support and potential new targets for COPD treatment.

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Publication Details

Journal
COPD Journal of Chronic Obstructive Pulmonary Disease
Published
2026-04-27
DOI
https://doi.org/10.1080/15412555.2026.2649605
Primary Topic
Chronic Obstructive Pulmonary Disease (COPD) Research
Type
article
Field-Weighted Citation Impact
0.00

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article

LncTUG1 Regulates miR-181a/ BPIFB4 Axis to Promote COPD Inflammation

Awaguli Tuersun, Zulipikaer Abudureheman, Ayiguli Alimu, Li Li et al.
COPD Journal of Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) Research
article

LncTUG1 Regulates miR-181a/ BPIFB4 Axis to Promote COPD Inflammation

Awaguli Tuersun, Zulipikaer Abudureheman, Ayiguli Alimu, Li Li, Jingran Xu, Tao Ma, Yun Chen, Lexin Xue, Yaping Zhou, Aifang Zheng, Xiuqi Lu
article en

Abstract

BACKGROUND: in COPD inflammatory processes. METHODS: , and miR-181a were detected by qPCR and western blot. Bioinformatic prediction and dual luciferase assays were used to predict the targeting relationship. Flow cytometry and ELISA assays evaluated the content of macrophages and inflammatory cytokines, respectively. RESULTS: 1 showed the opposite effects. CONCLUSIONS: promotes macrophage polarization toward the M2 type, thereby alleviating the inflammatory response in COPD. These findings provide theoretical support and potential new targets for COPD treatment.

COPD Journal of Chronic Obstructive Pulmonary DiseaseVol. 23(1)
Xinjiang Medical University (CN), Wuhan Pulmonary Hospital (CN), Hefei First People's Hospital (CN)
National Natural Science Foundation of China
Zero hunger
Openalex Percentile: Top 13%
Chronic Obstructive Pulmonary Disease (COPD) Research
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