Computer-Aided Rational Design Enhances 2- <i>O</i> -α-Glucosyl Glycerol Biosynthesis by Sucrose Phosphorylase in High-Viscosity Concentrated Substrates

-α-GG) production from 1.8 M sucrose and 2.16 M glycerol (a 208 g/L increase over the wild type) at 45 °C. This study highlights the industrial merits of rational integrated computational approaches, enabling efficient enzyme engineering for superior biocatalysis in high-viscosity systems.

Authors

Hao Liang (ORCID: https://orcid.org/0000-0002-4799-882X)
Shuyi Yao
Haichang Xu

Institutions

State Key Laboratory of Chemical Engineering (CN)
Beijing University of Chemical Technology (CN)

Publication Details

Journal: Journal of Agricultural and Food Chemistry
Published: 2026-04-27
DOI: https://doi.org/10.1021/acs.jafc.5c15606
Primary Topic: Enzyme Catalysis and Immobilization
Type: article
Field-Weighted Citation Impact: 0.00

Funders

National Natural Science Foundation of China
National Key Research and Development Program of China

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article

Computer-Aided Rational Design Enhances 2- O -α-Glucosyl Glycerol Biosynthesis by Sucrose Phosphorylase in High-Viscosity Concentrated Substrates

Hao Liang, Shuyi Yao, Haichang Xu

Apr 27, 2026

Journal of Agricultural and Food Chemistry

Enzyme Catalysis and Immobilization

article

Computer-Aided Rational Design Enhances 2- O -α-Glucosyl Glycerol Biosynthesis by Sucrose Phosphorylase in High-Viscosity Concentrated Substrates

Hao Liang, Shuyi Yao, Haichang Xu

April 27, 2026article en

Abstract

-α-GG) production from 1.8 M sucrose and 2.16 M glycerol (a 208 g/L increase over the wild type) at 45 °C. This study highlights the industrial merits of rational integrated computational approaches, enabling efficient enzyme engineering for superior biocatalysis in high-viscosity systems.

Journal of Agricultural and Food ChemistryVol. 74(17)

State Key Laboratory of Chemical Engineering (CN), Beijing University of Chemical Technology (CN)

National Natural Science Foundation of China, National Key Research and Development Program of China

Industry, innovation and infrastructure

Openalex Percentile: Top 16%

Enzyme Catalysis and Immobilization

DOI Source OpenAlex

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