A pH-responsive layered double hydroxide nanoradiosensitizer for bone metastasis tumor
, CaGd-LDH combined with X-ray irradiation inhibits tumor growth, reduces cell proliferation, activates pyroptosis, and suppresses lung metastasis in a breast cancer bone metastasis mouse model. This multifunctional CaGd-LDH integrates radiosensitization, pyroptosis induction, and good biocompatibility, offering a promising strategy to improve local therapy and inhibit distant metastasis in breast cancer bone metastasis.
Authors
- Zhanjun Gu (ORCID: https://orcid.org/0000-0003-3717-2423)
- Jiangfeng Du (ORCID: https://orcid.org/0000-0002-8533-5509)
- Miao Zhu
- Shuo Shi
- Shuang Zhu
- Chen Yang
- Xue Wang (ORCID: https://orcid.org/0009-0003-7746-0283)
Institutions
- Shanxi Medical University (CN)
- China Spallation Neutron Source (CN)
- First Hospital of Shanxi Medical University (CN)
- Institute of High Energy Physics (CN)
Publication Details
- Journal
- Materials Today Bio
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1016/j.mtbio.2026.103165
- Primary Topic
- Layered Double Hydroxides Synthesis and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Ministry of Science and Technology of the People's Republic of China
- Natural Science Foundation of Beijing Municipality