LANTERN: Leveraging Local Ancestry Tracts to Enhance Rare-Variant Aggregate Association Testing
was associated with HGB and RBC. In summary, LANTERN (i) allows for the identification of ancestry-specific rare-variant associations; and (ii) enhances rare-variant association signals compared to an analysis that ignores local ancestry. LANTERN is implemented in R and is freely available on GitHub.
Authors
- Laura M. Raffield (ORCID: https://orcid.org/0000-0002-7892-193X)
- Paul Livermore Auer (ORCID: https://orcid.org/0000-0003-1735-8044)
- Bjoernar Tuftin (ORCID: https://orcid.org/0009-0001-6486-3708)
- Sarah Kerns
- Bertha Hidalgo
- Andrew T DeWan
- Suzanne M. Leal
- Yu Wang
Institutions
- University of North Carolina at Chapel Hill (US)
- Medical College of Wisconsin (US)
- Columbia University Irving Medical Center (US)
- University of Alabama at Birmingham (US)
- Yale University (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-04-27
- DOI
- https://doi.org/10.64898/2026.04.24.26351693
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00