Discovery of Tetrahydropyrrolo[3,4‐c]pyrrole‐1,3‐dione Derivatives as Novel RIPK1 Inhibitors via Pharmacophore‐Based Virtual Screening

= 15.32 μM). Molecular dynamics (MD) simulations indicated that it probably functioned as a type III kinase inhibitor.

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Publication Details

Journal
Drug Development Research
Published
2026-04-27
DOI
https://doi.org/10.1002/ddr.70290
Primary Topic
Cell death mechanisms and regulation
Type
article
Field-Weighted Citation Impact
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article

Discovery of Tetrahydropyrrolo[3,4‐c]pyrrole‐1,3‐dione Derivatives as Novel RIPK1 Inhibitors via Pharmacophore‐Based Virtual Screening

Rong Sheng, G Chen, Yanzhen Yu, Yifan Wu et al.
Drug Development Research
Cell death mechanisms and regulation
article

Discovery of Tetrahydropyrrolo[3,4‐c]pyrrole‐1,3‐dione Derivatives as Novel RIPK1 Inhibitors via Pharmacophore‐Based Virtual Screening

Rong Sheng, G Chen, Yanzhen Yu, Yifan Wu, Xin Zeng
article en

Abstract

= 15.32 μM). Molecular dynamics (MD) simulations indicated that it probably functioned as a type III kinase inhibitor.

Drug Development ResearchVol. 87(3)
Jinhua Academy of Agricultural Sciences (CN), Zhejiang University (CN)
Openalex Percentile: Top 7%
Cell death mechanisms and regulation
DOISourceOpenAlex
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