Host GPCR-cAMP signaling balances Gαs and Gαi activity to control intracellular <i>Brucella</i> infection

engages to establish its intracellular niche and suggest that targeting host signaling dynamics, rather than bacterial viability directly, may provide new strategies to block intracellular infection.

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Publication Details

Journal
mBio
Published
2026-04-27
DOI
https://doi.org/10.1128/mbio.00040-26
Primary Topic
Brucella: diagnosis, epidemiology, treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

Host GPCR-cAMP signaling balances Gαs and Gαi activity to control intracellular Brucella infection

James E. Kirby, Yoon-Suk Kang
mBio
Brucella: diagnosis, epidemiology, treatment
article

Host GPCR-cAMP signaling balances Gαs and Gαi activity to control intracellular Brucella infection

James E. Kirby, Yoon-Suk Kang
article en

Abstract

engages to establish its intracellular niche and suggest that targeting host signaling dynamics, rather than bacterial viability directly, may provide new strategies to block intracellular infection.

mBio
Beth Israel Deaconess Medical Center (US)
Massachusetts Life Sciences Center, National Institute of Allergy and Infectious Diseases
Openalex Percentile: Top 5%
Brucella: diagnosis, epidemiology, treatment
DOIOpen Access PDFOpenAlex
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