CRL4AMBRA1 is a key mediator for AKT-dependent cell cycle control in neural progenitor cells
, which disrupts its interaction with CCND2 and reduces its degradation. These findings reveal a post-translational mechanism impacting NPC cell cycle and cortical morphogenesis, providing insight into the etiology of malformations of cortical development.
Authors
- Runmin Wang (ORCID: https://orcid.org/0000-0001-9687-9918)
- Tingting Zhu (ORCID: https://orcid.org/0000-0002-1552-5630)
- Guiquan Chen (ORCID: https://orcid.org/0000-0002-4674-5548)
- Jie Yang (ORCID: https://orcid.org/0000-0003-4801-7162)
- Panmiao Liu
- He Wang (ORCID: https://orcid.org/0009-0007-1938-164X)
- Hanwen Gu
Institutions
- Model Animal Research Center (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- EMBO Reports
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1038/s44319-026-00768-7
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Zhengzhou University
- Nanjing Medical University
- First Affiliated Hospital of Zhengzhou University