<scp>PLP</scp> Homeostasis Protein Is Required for Efficient Maturation of Aromatic Amino Acid Aminotransferase in <i>Salmonella enterica</i>

vitamer PMP, or upregulation of pyridoxal kinase (PdxK). Using TyrB as a target, we provide the first demonstration that YggS of S. enterica can mediate transfer of PLP to a PLP-DE in vitro. In total, this study defines multiple in vivo maturation pathways for TyrB and provides a working model for the role of YggS in the maturation of TyrB.

Authors

Institutions

Publication Details

Journal
Molecular Microbiology
Published
2026-04-27
DOI
https://doi.org/10.1111/mmi.70072
Primary Topic
Enzyme Structure and Function
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

PLP Homeostasis Protein Is Required for Efficient Maturation of Aromatic Amino Acid Aminotransferase in Salmonella enterica

Diana M. Downs, Brandi A. Buckner
Molecular Microbiology
Enzyme Structure and Function
article

PLP Homeostasis Protein Is Required for Efficient Maturation of Aromatic Amino Acid Aminotransferase in Salmonella enterica

Diana M. Downs, Brandi A. Buckner
article en

Abstract

vitamer PMP, or upregulation of pyridoxal kinase (PdxK). Using TyrB as a target, we provide the first demonstration that YggS of S. enterica can mediate transfer of PLP to a PLP-DE in vitro. In total, this study defines multiple in vivo maturation pathways for TyrB and provides a working model for the role of YggS in the maturation of TyrB.

Molecular Microbiology
University of Georgia (US)
National Institutes of Health
Openalex Percentile: Top 9%
Enzyme Structure and Function
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.