<scp>PLP</scp> Homeostasis Protein Is Required for Efficient Maturation of Aromatic Amino Acid Aminotransferase in <i>Salmonella enterica</i>
vitamer PMP, or upregulation of pyridoxal kinase (PdxK). Using TyrB as a target, we provide the first demonstration that YggS of S. enterica can mediate transfer of PLP to a PLP-DE in vitro. In total, this study defines multiple in vivo maturation pathways for TyrB and provides a working model for the role of YggS in the maturation of TyrB.
Authors
- Diana M. Downs (ORCID: https://orcid.org/0000-0002-1564-6205)
- Brandi A. Buckner (ORCID: https://orcid.org/0000-0002-7173-7312)
Institutions
- University of Georgia (US)
Publication Details
- Journal
- Molecular Microbiology
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1111/mmi.70072
- Primary Topic
- Enzyme Structure and Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health