Structural basis for phosphorylation and allosteric regulation of bacterial glycogen phosphorylase by histidine phosphocarrier protein
GP. We establish histidine phosphorylation as a mechanism of GP regulation, expanding the traditional paradigm of glycogen metabolism control in bacteria.
Authors
- Tom Desmet (ORCID: https://orcid.org/0000-0002-5788-3022)
- Ricardo M. Biondi (ORCID: https://orcid.org/0000-0002-8873-7167)
- Emma De Beul (ORCID: https://orcid.org/0000-0002-9593-3182)
- Weston B. Struwe (ORCID: https://orcid.org/0000-0003-0594-226X)
- Leonardo Mastrella (ORCID: https://orcid.org/0000-0001-7356-936X)
- Sean R. Connell (ORCID: https://orcid.org/0000-0001-7807-7049)
- Marcelo E. Guerin (ORCID: https://orcid.org/0000-0001-9524-3184)
- Jorick Franceus (ORCID: https://orcid.org/0000-0003-4377-5933)
- Francisco Paredes‐Martínez (ORCID: https://orcid.org/0009-0004-2654-031X)
- Elena Holden
- Patricia Casino (ORCID: https://orcid.org/0000-0002-2144-188X)
- Christophe Colleoni (ORCID: https://orcid.org/0000-0002-6534-6120)
- Cecilia D’Angelo (ORCID: https://orcid.org/0000-0001-9645-8056)
- Alberto Marina (ORCID: https://orcid.org/0000-0002-1334-5273)
- Javier O. Cifuente (ORCID: https://orcid.org/0000-0001-5420-121X)
- Valerio Di Domenico (ORCID: https://orcid.org/0000-0002-8040-5854)
- Justin L. P. Benesch (ORCID: https://orcid.org/0000-0002-1507-3742)
- Adrià Alcaide-Jiménez
- Alejandro Delgado Rey (ORCID: https://orcid.org/0000-0002-8869-3790)
- Juan Carlos Villegas-Ruiz (ORCID: https://orcid.org/0009-0007-3831-5285)
Institutions
- Ikerbasque (ES)
- Centre National de la Recherche Scientifique (FR)
- Consejo Superior de Investigaciones Científicas (ES)
- Universitat de València (ES)
- University of the Basque Country (ES)
- Université de Lille (FR)
- Discovery Centre (CA)
- Ghent University (BE)
- University of Oxford (GB)
- BioCruces Health research Institute (ES)
- Unité de Glycobiologie Structurale et Fonctionnelle (FR)
- Hospital de Cruces (ES)
- Institute for Scientific and Technological Research (MX)
- Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society (AR)
- Instituto de Biomedicina de Valencia (ES)
- Instituto de Investigación de Enfermedades Raras (ES)
- Institut de Biologia Molecular de Barcelona (ES)
Publication Details
- Journal
- Nature Communications
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1038/s41467-026-71729-w
- Primary Topic
- Bacterial Genetics and Biotechnology
- Type
- article
- Field-Weighted Citation Impact
- 0.00