New Reversible Covalent Warheads: Cyanobenzothiazoles Recruiting DCAF16 for Targeted Protein Degradation
and HER2 without hook effects, outperforming clinical inhibitors. This work provides the first proteome-wide map of ligandable NCys residues and establishes CBT as a versatile platform for covalent targeted protein degradation (TPD), opening new avenues for precision therapeutics.
Authors
- T Liu
- Jixian Zhang (ORCID: https://orcid.org/0000-0003-3933-2558)
- Yi Tan (ORCID: https://orcid.org/0000-0002-0619-1173)
- Li Z
- Yifang Li
- Shengrong Li
- Lei Huang
Institutions
- Shihezi University (CN)
- Jinan University (CN)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1021/acs.jmedchem.6c00889
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00