Base and Ligand-Free Silver-Catalyzed C <sub>sp</sub> –H Thiolation of Terminal Alkynes with <i>N</i> -Thiosuccinimides
-thiosuccinimides via silver catalysis. The reaction proceeds under mild, base-, and ligand-free conditions, enabling the construction of alkynyl sulfides in good to excellent yields. The key advantages of this protocol are that it enables the omission of external bases and ligands, offers operational simplicity, and maintains broad functional group tolerance. This method offers a simple and effective alternative for synthesizing versatile alkynyl sulfide derivatives, with potential applications in pharmaceutical and materials chemistry.
Authors
- Heng Xu (ORCID: https://orcid.org/0000-0002-1720-5286)
- Yan Dong (ORCID: https://orcid.org/0000-0003-2654-5191)
- Fenghua Liu (ORCID: https://orcid.org/0000-0002-1785-2766)
- Mengmeng Li (ORCID: https://orcid.org/0000-0002-6317-875X)
- Haixu Ren
Institutions
- Guiyang Medical University (CN)
- Jiamusi University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Shanghai Institute of Materia Medica (CN)
- Institute of Medicinal Plant Development (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1021/acs.joc.6c00002
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Academy of Medical Sciences
- Guizhou Science and Technology Corporation Platform Talents Fund
- State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University