Multivariate equivalence and component-wise superiority tests for paired samples

Most existing multivariate equivalence and superiority tests have been developed for two-sample settings, while methods for one-sample settings remain scarce. Moreover, most multivariate superiority tests combine superiority and non-inferiority tests rather than providing a purely one-sided test of joint superiority. To fill these gaps, we adapt the existing Intersection-Union Test and propose Likelihood Ratio Nonparametric and Parametric Bootstrap Tests for paired multivariate equivalence and component-wise superiority testing. Simulation studies demonstrate the ability of the proposed approach to detect equivalence and component-wise superiority while maintaining control of type I error rates. An application to real data further illustrates the practical utility of the approach. Overall, combining classical likelihood methods with bootstrap resampling yields a powerful and flexible solution for paired multivariate equivalence and component-wise superiority testing.

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Publication Details

Journal
Journal of Biopharmaceutical Statistics
Published
2026-04-27
DOI
https://doi.org/10.1080/10543406.2026.2663455
Primary Topic
Statistical Methods in Clinical Trials
Type
article
Field-Weighted Citation Impact
0.00

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article

Multivariate equivalence and component-wise superiority tests for paired samples

Vernon M. Chinchilli, Yanxi Hu
Journal of Biopharmaceutical Statistics
Statistical Methods in Clinical Trials
article

Multivariate equivalence and component-wise superiority tests for paired samples

Vernon M. Chinchilli, Yanxi Hu
article en

Abstract

Most existing multivariate equivalence and superiority tests have been developed for two-sample settings, while methods for one-sample settings remain scarce. Moreover, most multivariate superiority tests combine superiority and non-inferiority tests rather than providing a purely one-sided test of joint superiority. To fill these gaps, we adapt the existing Intersection-Union Test and propose Likelihood Ratio Nonparametric and Parametric Bootstrap Tests for paired multivariate equivalence and component-wise superiority testing. Simulation studies demonstrate the ability of the proposed approach to detect equivalence and component-wise superiority while maintaining control of type I error rates. An application to real data further illustrates the practical utility of the approach. Overall, combining classical likelihood methods with bootstrap resampling yields a powerful and flexible solution for paired multivariate equivalence and component-wise superiority testing.

Journal of Biopharmaceutical Statistics
Pennsylvania State University (US)
National Institute of Diabetes and Digestive and Kidney Diseases
Openalex Percentile: Top 14%
Statistical Methods in Clinical Trials
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