Multivariate equivalence and component-wise superiority tests for paired samples
Most existing multivariate equivalence and superiority tests have been developed for two-sample settings, while methods for one-sample settings remain scarce. Moreover, most multivariate superiority tests combine superiority and non-inferiority tests rather than providing a purely one-sided test of joint superiority. To fill these gaps, we adapt the existing Intersection-Union Test and propose Likelihood Ratio Nonparametric and Parametric Bootstrap Tests for paired multivariate equivalence and component-wise superiority testing. Simulation studies demonstrate the ability of the proposed approach to detect equivalence and component-wise superiority while maintaining control of type I error rates. An application to real data further illustrates the practical utility of the approach. Overall, combining classical likelihood methods with bootstrap resampling yields a powerful and flexible solution for paired multivariate equivalence and component-wise superiority testing.
Authors
- Vernon M. Chinchilli (ORCID: https://orcid.org/0000-0001-6488-7809)
- Yanxi Hu
Institutions
- Pennsylvania State University (US)
Publication Details
- Journal
- Journal of Biopharmaceutical Statistics
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1080/10543406.2026.2663455
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Diabetes and Digestive and Kidney Diseases