Prognostic Significance of the Tumour Microenvironment in Surgically Resected Canine Pulmonary Adenocarcinomas
, respectively. Tumours with LAs showed higher CD20+ and Foxp3+ cell densities than tumours without LAs. Median PFI and OST were 754 days (95% CI, 375-not reached) and 716 days (95% CI, 399-936), respectively. In multivariable analysis, tumour size classification, lymph node metastasis, surgical margin status and the presence of LAs were independently associated with shorter PFI. Age, lymph node metastasis and the CD8/Foxp3 ratio were independently associated with OST. These findings indicate that immunohistochemical features may provide additional prognostic information for postoperative risk stratification in cPACs and complement established clinicopathological factors.
Authors
- Fukiko Matsuyama (ORCID: https://orcid.org/0000-0002-1021-7735)
- Takuya Mizuno (ORCID: https://orcid.org/0000-0002-9580-7557)
- Masanao Ichimata (ORCID: https://orcid.org/0000-0003-0925-0981)
- Eri Fukazawa
- Atsushi Toshima (ORCID: https://orcid.org/0009-0000-5190-6396)
- Ryuzo Katayama
- Yuko Nakano (ORCID: https://orcid.org/0000-0001-7583-004X)
- Masaya Igase (ORCID: https://orcid.org/0000-0002-3118-8507)
- Tetsuya Kobayashi (ORCID: https://orcid.org/0000-0002-0100-8579)
- Kei Harada (ORCID: https://orcid.org/0000-0002-3345-9200)
- Yumiko Kagawa (ORCID: https://orcid.org/0009-0006-0078-1443)
Institutions
- Yamaguchi University (JP)
- Hokkaido University (JP)
- Japan Small Animal Medical Center (JP)
Publication Details
- Journal
- Veterinary and Comparative Oncology
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1111/vco.70075
- Primary Topic
- Veterinary Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00