Multifunctional injectable hydrogel with Zn-metformin coordination for synergistic anti-infection, antioxidant, and osteogenic therapy in periodontitis
, PgC@ZM effectively accelerates osteogenic therapy in rat periodontitis by synchronously alleviating tissue inflammation and inhibiting alveolar bone resorption. Overall, this multifunctional hydrogel presents a comprehensive and promising approach for treating periodontitis, with significant potential for clinical translation.
Authors
- Miao Zhang (ORCID: https://orcid.org/0000-0002-7291-8852)
- Fangze Guo
- Yanjing Ji (ORCID: https://orcid.org/0000-0002-4814-7648)
- Guotai Li
- Changqing Yuan
- Danyang Wang
- Xiaoyu Chen
- Qihui Zhou (ORCID: https://orcid.org/0000-0003-2474-4197)
Institutions
- Qingdao University (CN)
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Affiliated Hospital of Qingdao University (CN)
- Ocean University of China (CN)
Publication Details
- Journal
- Materials Today Bio
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1016/j.mtbio.2026.103148
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province