Toward High Performance Liquid Chromatography with Hierarchically Porous Metal Organic Framework Spheres (HP-MOFS)

materials. Apart from high efficiencies, HP-MOFS exhibited excellent stability in solvents commonly used in column packing and mobile phase preparation, and what's more, maintained a good structural integrity under high operating pressures up to 40 MPa. These findings indicate that HP-MOFS, as a synergetic combination of spherical morphology and hierarchically porous architecture, can effectively improve the performance of MOFs in liquid phase separations. From a precision manufacturing standpoint, the results suggest that it is the pore design and morphology control that play the central role in developing high performance MOF chromatography.