Erbin Confers Neuroprotection Against Cerebral Ischemia-Reperfusion Injury in Mice via MAPK Pathway Inhibition

This study reveals that Erbin overexpression protects against cerebral ischemia-reperfusion injury by inhibiting MAPK pathway activation, specifically by inhibiting the phosphorylation of ERK and p38. Erbin mitigates infarct volume, improves neurological function, and suppresses inflammatory cytokines in both in vivo and in vitro models. These findings highlight Erbin as a potential therapeutic target for ischemic stroke, offering a novel strategy to combat neuroinflammation and neuronal damage.