Asymmetric Synthesis of <i>S</i> -Trifluoromethyl Sulfoxide and Sulfoximine Pharmacophores
-acyl group is first cleaved to give the free-NH sulfilimine that then undergoes hydrolysis by backside displacement of the amine to give the sulfoxide with inversion of stereochemistry.
Authors
- Jonathan A. Ellman (ORCID: https://orcid.org/0000-0001-9320-5512)
- Justin Ye
- Na Yeon Kwon (ORCID: https://orcid.org/0000-0003-2776-4863)
Institutions
- Yale University (US)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1021/jacs.6c03062
- Primary Topic
- Synthesis and Catalytic Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of General Medical Sciences