Comorbidity Clusters in Acute Heart Failure: Insights From the AMERICCAASS Registry
BACKGROUND: Acute heart failure (HF) frequently coexists with multimorbidity. Comorbidity clusters have been associated with distinct clinical outcomes, but data from the Americas remain limited. We aimed to identify comorbidity clusters in patients with acute HF and assess their association with in-hospital outcomes. METHODS: This cohort study applied latent class analysis to patients from the AMERICCAASS Registry (Registro Americano de Insuficiencia Cardiaca Ambulatoria o Agudamente descompensada). Adjusted Poisson regression assessed in-hospital mortality and intensive care unit (ICU) admission, and multivariable analysis identified independent predictors of ICU admission. RESULTS: <0.001), compared with Cluster 1. Severe valvular insufficiency, peripheral artery disease, dyslipidemia, cancer, acute coronary syndrome, anemia, and cardiogenic shock were associated with higher ICU admission risk. CONCLUSIONS: Patients with acute HF in the Americas exhibit distinct comorbidity patterns associated with different clinical profiles and ICU admission rates, which may inform risk stratification and management strategies. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique Identifier: NCT05295641.
Authors
- Miguel Quintana (ORCID: https://orcid.org/0009-0001-9322-629X)
- Maikel Santos Medina (ORCID: https://orcid.org/0000-0002-2123-9577)
- Luis Pérez-Plata
- Alexander Romero (ORCID: https://orcid.org/0000-0002-0785-0804)
- Walter Alarco (ORCID: https://orcid.org/0000-0001-5881-4080)
- Adrián Lescano (ORCID: https://orcid.org/0000-0002-9015-8666)
- Tessa Negrín Valdés
- Daniel Quesada (ORCID: https://orcid.org/0000-0003-4367-549X)
- Juan Pablo Arango-Ibañez (ORCID: https://orcid.org/0000-0003-3601-3279)
- Luis Eduardo Echeverría (ORCID: https://orcid.org/0000-0001-5784-3859)
- Mario Speranza (ORCID: https://orcid.org/0000-0002-1785-5764)
- Juan Esteban Gómez‐Mesa (ORCID: https://orcid.org/0000-0002-6635-6224)
- Mark H. Drazner (ORCID: https://orcid.org/0000-0003-3054-4757)
- Alexander Romero Guerra
- Andrea Valencia (ORCID: https://orcid.org/0000-0001-6855-207X)
- Víctor Rossel (ORCID: https://orcid.org/0000-0002-4212-1148)
- Juan Andrés Muñoz-Ordoñez (ORCID: https://orcid.org/0009-0009-1278-8943)
- Valeria Azcárate-Rodríguez (ORCID: https://orcid.org/0009-0007-8219-9285)
- Mario Miguel Barbosa Rengifo
- Sebastián Seni-Molina (ORCID: https://orcid.org/0009-0006-2151-0722)
- Daniel Quesada Chaves
- C S P Lam
- Paola Oliver Rengifo
- Eduardo R. Perna
- Juan Esteban Gómez Mesa
- Harold Segundo Cedeño Macias (ORCID: https://orcid.org/0009-0009-9063-9062)
- Víctor Alejandro Rossel Mariángel
- Mario Osvaldo Speranza
- Sebastian Seni Molina
- José Jesús Marval (ORCID: https://orcid.org/0009-0003-5879-8246)
- Juan Pablo Allende
Institutions
- National University of Quilmes (AR)
- Universidad de Ciencias Médicas de Cienfuegos (CU)
- Sonora Institute of Technology (MX)
- Centro Cardiologico Monzino (IT)
- Fundación Cardiovascular de Colombia (CO)
- Fundación Valle del Lili (CO)
- Instituto Nacional del Tórax (CL)
- Corporación Universitaria de Ciencia y Desarrollo (CO)
- Hospital São Vicente (BR)
- Saint Thomas Hospital (PA)
- Duke-NUS Medical School (SG)
- Universidad Bíblica Latinoamericana (CR)
- National Heart Centre Singapore (SG)
- Sociedad Española de Cardiología (ES)
- Nelson Hospital (GB)
- Southwestern Medical Center (US)
- University of Chile (CL)
- Icesi University (CO)
- The University of Texas Southwestern Medical Center (US)
- Tecnológico de Monterrey (MX)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1161/jaha.125.046820
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidad de Santiago de Chile
- Departamento de Investigaciones Científicas y Tecnológicas, Universidad de Santiago de Chile