Parkinson’s disease-associated LRRK2 risk variant, G2385R, enhances Rab substrate phosphorylation and impairs neuronal integrity
coding variants and demonstrates that the PD risk variant, G2385R LRRK2, creates a hyperactive kinase that can impair neuronal integrity at comparable levels to the effects of G2019S LRRK2.
Authors
- Lindsey A. Cunningham
- An Phu Tran Nguyen
- Roger Moser
- Evan J. Worden (ORCID: https://orcid.org/0000-0003-0644-166X)
- Darren J. Moore (ORCID: https://orcid.org/0000-0003-2359-5679)
- Nicole Bryant (ORCID: https://orcid.org/0009-0004-7827-9205)
Institutions
- Van Andel Institute (US)
- Duke University (US)
- University of Wisconsin–Milwaukee (US)
- École Polytechnique Fédérale de Lausanne (CH)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-27
- DOI
- https://doi.org/10.64898/2026.04.23.720426
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health