Structural Characterization and Deconstruction of Polysaccharides from <i>Chenopodium quinoa</i> Willd. Bran: Mechanistic Insights into Their Protective Effects against Colitis

-(1→. CWBP-2-1 exhibits preventive effects against dextran sodium sulfate (DSS)-induced colitis. It can alleviate tissue damage and inflammatory symptoms of colitis and inhibit the NF-κB signaling pathway. CWBP-2-1 relieved the imbalance in the gut microbiota caused by DSS and inhibited the growth of harmful bacteria. Additionally, metabolomic analysis of the colon and liver indicated that CWBP-2-1 could prevent metabolic disorders caused by DSS-induced colitis in the gut-liver axis. These results suggest that CWBP-2-1 exhibits preventive potential against DSS-induced colitis in mice and may serve as a promising plant-derived polysaccharide for further investigation in intestinal health-related research.