Zoster-Like Dermatomal Eruption Following Recombinant Zoster Vaccine: A Case Report

The reactivation of the varicella zoster virus (VZV) is the cause of herpes zoster (HZ), usually referred to as shingles. Once an individual has been previously infected with chickenpox, the virus stays dormant in their nervous system and may reactivate later in life, leading to HZ. HZ poses a significant burden on the healthcare system due to its high prevalence. Older adults and individuals with compromised immune function are at higher risk of viral reactivation. Vaccination against HZ is a highly effective strategy in preventing viral recurrence and its associated complications. However, recognizing rare post-vaccination zoster-like cutaneous eruptions is essential. In this report, we present a rare instance of a clinically suspected HZ-like eruption in an 85-year-old man who developed an erythematous maculopapular rash with scattered vesicular lesions on his right neck and shoulder one day after receiving a standard dosage vaccine. The patient was treated with valacyclovir for seven days. The immediate recognition of healthcare professionals is the aim of this report to promote early diagnosis and treatment.

Authors

Publication Details

Journal
Cureus
Published
2026-04-27
DOI
https://doi.org/10.7759/cureus.107834
Primary Topic
Herpesvirus Infections and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Zoster-Like Dermatomal Eruption Following Recombinant Zoster Vaccine: A Case Report

Amal A Kokandi, Reem Alzahrani, Zubaida H. Khan, Ahlam H Alsulami et al.
Cureus
Herpesvirus Infections and Treatments
article

Zoster-Like Dermatomal Eruption Following Recombinant Zoster Vaccine: A Case Report

Amal A Kokandi, Reem Alzahrani, Zubaida H. Khan, Ahlam H Alsulami, Rawabi M Shaikh
article en

Abstract

The reactivation of the varicella zoster virus (VZV) is the cause of herpes zoster (HZ), usually referred to as shingles. Once an individual has been previously infected with chickenpox, the virus stays dormant in their nervous system and may reactivate later in life, leading to HZ. HZ poses a significant burden on the healthcare system due to its high prevalence. Older adults and individuals with compromised immune function are at higher risk of viral reactivation. Vaccination against HZ is a highly effective strategy in preventing viral recurrence and its associated complications. However, recognizing rare post-vaccination zoster-like cutaneous eruptions is essential. In this report, we present a rare instance of a clinically suspected HZ-like eruption in an 85-year-old man who developed an erythematous maculopapular rash with scattered vesicular lesions on his right neck and shoulder one day after receiving a standard dosage vaccine. The patient was treated with valacyclovir for seven days. The immediate recognition of healthcare professionals is the aim of this report to promote early diagnosis and treatment.

Cureus
Zero hunger
Openalex Percentile: Top 7%
Herpesvirus Infections and Treatments
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