Deep learning–driven prediction of on-target activity, off-target risk, and repair outcomes in CRISPR/Cas9: current landscape and multi-scale perspectives

Authors

Haoyang Zhang (ORCID: https://orcid.org/0000-0002-8036-4917)
Xiangxing Zhu (ORCID: https://orcid.org/0000-0002-5265-2620)
Hong Hu
Chao Liu
Yangyang Zheng
Linyuan Guo
Tingfeng Zhang
Dongsheng Tang
Ling Chen
Weian Du

Institutions

Foshan University (CN)
Jinan University (CN)
Lund University (SE)
Southern University of Science and Technology (CN)
Laboratoire de Chémo-biologie synthétique et thérapeutique (FR)
Shenzhen Second People's Hospital (CN)
Southern Medical University (CN)

Publication Details

Journal: Journal of Translational Medicine
Published: 2026-04-28
DOI: https://doi.org/10.1186/s12967-026-08175-1
Primary Topic: CRISPR and Genetic Engineering
Type: article
Field-Weighted Citation Impact: 0.00

Funders

National Natural Science Foundation of China

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article

Deep learning–driven prediction of on-target activity, off-target risk, and repair outcomes in CRISPR/Cas9: current landscape and multi-scale perspectives

Haoyang Zhang, Xiangxing Zhu, Hong Hu, Chao Liu et al.

Apr 28, 2026

Journal of Translational Medicine

CRISPR and Genetic Engineering

article

Deep learning–driven prediction of on-target activity, off-target risk, and repair outcomes in CRISPR/Cas9: current landscape and multi-scale perspectives

Haoyang Zhang, Xiangxing Zhu, Hong Hu, Chao Liu, Yangyang Zheng, Linyuan Guo, Tingfeng Zhang, Dongsheng Tang, Ling Chen, Weian Du

April 28, 2026article en

Abstract

No abstract available for this paper.

Journal of Translational Medicine

Foshan University (CN), Jinan University (CN), Lund University (SE), Southern University of Science and Technology (CN), Laboratoire de Chémo-biologie synthétique et thérapeutique (FR), Shenzhen Second People's Hospital (CN), Southern Medical University (CN)

National Natural Science Foundation of China

Climate action

Openalex Percentile: Top 17%

CRISPR and Genetic Engineering

DOI Open Access PDF OpenAlex

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