Bidirectional regulation between circadian feeding behavior and specialized midgut clocks in <i>Drosophila</i>
feeding in constant darkness, whereas feeding/fasting cycles enable the autonomous persistence of clock oscillations in EECs but not in ECs. These findings are suggestive of regulatory feedback between midgut EECs and feeding, highlighting how timed feeding or dietary interventions could influence metabolic health via specialized gut cells.
Authors
- William W. Ja (ORCID: https://orcid.org/0000-0002-4003-7356)
- Binbin Wu (ORCID: https://orcid.org/0000-0002-0879-4904)
Institutions
- The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-27
- DOI
- https://doi.org/10.64898/2026.04.23.720414
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute on Deafness and Other Communication Disorders