Alkyl Radical Coupling with Phenoxy(imine)–Nickel(II)–Aryl Complexes: Evidence for a Multistep Process in C–C Bond Formation
C kinetic isotope effect measurements and computational studies are also consistent with this pathway. Treatment of phenoxy(imine)-nickel(II)-aryl complexes with various oxidants generated transient nickel(III) complexes that were detected by electron paramagnetic resonance (EPR) spectroscopy and intercepted by organozinc reagents to generate C-C bond formation products, supporting the intermediacy of this oxidation state in the overall process.
Authors
- Eric M. Simmons (ORCID: https://orcid.org/0000-0002-3854-1561)
- Matthew V. Joannou (ORCID: https://orcid.org/0000-0002-0079-7107)
- Marina Pérez‐Jiménez (ORCID: https://orcid.org/0000-0001-7891-4273)
- L. Reginald Mills (ORCID: https://orcid.org/0000-0002-6329-2368)
- Steven R. Wisniewski (ORCID: https://orcid.org/0000-0001-6035-4394)
- Heejun Lee (ORCID: https://orcid.org/0000-0002-0439-3863)
- Paul J. Chirik (ORCID: https://orcid.org/0000-0001-8473-2898)
- Karla Ravin
- Hao Liang
Institutions
- University of Geneva (CH)
- Bristol-Myers Squibb (Germany) (DE)
- Princeton University (US)
- University of Houston (US)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1021/jacs.6c02912
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bristol-Myers Squibb