MedSpectralNet: A lightweight convolutional neural network architecture for multi-modal image classification
Medical image classification requires models that effectively capture both fine-grained local patterns and global anatomical structures while maintaining computational efficiency for clinical deployment. Although state-of-the-art models such as MedMamba utilize State-Space Models (SSMs) to balance accuracy and efficiency, their sequential operations limit parallelism and increase runtime. To overcome these limitations, we propose MedSpectralNet, a lightweight Convolutional Neural Network (CNN) architecture that approximates self-attention with linear complexity to efficiently extract multi-frequency features. The model introduces a dual-stream feature extractor that processes global and local information in parallel, and a ContextGate block that adaptively fuses multi-scale representations. MedSpectralNet is evaluated across six benchmark datasets from MedMNIST (including BloodMNIST, BreastMNIST, DermaMNIST, PneumoniaMNIST, OrganCMNIST, and OrganSMNIST), MedSpectralNet achieves an average accuracy of 93.7% on OrganCMNIST and 98.0% on BloodMNIST, showing 1-4.3% relative accuracy gains when compared to larger transformer-based models. Importantly, it delivers this performance with only 8.5 million parameters, representing approximately 60% fewer parameters than MedMamba-T, which requires 14.5 million parameters. MedSpectralNet has also achieved high AUC values up to 0.999 across multiple classes, demonstrating state-of-the-art accuracy with substantially reduced computational cost and improved parallelization, which makes MedSpectralNet well-suited for real-time and resource-constrained classification-based medical applications.
Authors
- Ersin Elbaşı (ORCID: https://orcid.org/0000-0002-8603-1435)
- Yazan M. Allawi (ORCID: https://orcid.org/0000-0002-9635-5951)
- Salman Md Sultan (ORCID: https://orcid.org/0000-0001-9190-6841)
- Aymen I. Zreikat (ORCID: https://orcid.org/0000-0003-4900-497X)
- Wasan Alamro (ORCID: https://orcid.org/0000-0002-2190-9235)
- Ahmad Abadleh
- Nabilah Afrin
- Masud An-Nur Islam Fahim
Institutions
- Al-Ahliyya Amman University (JO)
- Princess Nourah bint Abdulrahman University (SA)
- Mutah University (JO)
- American University of the Middle East (KW)
- Innovative Research (United States) (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1371/journal.pone.0346128
- Primary Topic
- AI in cancer detection
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Princess Nourah Bint Abdulrahman University