Circulating Tumor DNA Assessment of Disease Response in Large B-Cell Lymphoma: Lisocabtagene Maraleucel Versus Autologous Stem Cell Transplantation Standard Therapy
remained significantly associated with EFS after adjusting for positron emission tomography (PET) response, while interaction testing revealed a significant interaction between PET status and treatment arm for EFS. Liso-cel achieved deeper, more durable molecular clearance by ctDNA, consistent with superior EFS and PFS versus ASCT for second-line LBCL treatment. ctDNA-MRD provided prognostic value beyond PET, supporting its role as a complementary biomarker for treatment response and relapse prediction.
Authors
- Manali Kamdar (ORCID: https://orcid.org/0000-0002-1930-152X)
- Scott R. Solomon (ORCID: https://orcid.org/0000-0003-2061-8126)
- Ash A. Alizadeh (ORCID: https://orcid.org/0000-0002-5153-5625)
- Koji Izutsu (ORCID: https://orcid.org/0000-0001-9129-8057)
- Pim G. N. J. Mutsaers (ORCID: https://orcid.org/0000-0002-3924-8578)
- Sami Ibrahimi (ORCID: https://orcid.org/0000-0002-7538-346X)
- Mazyar Shadman (ORCID: https://orcid.org/0000-0002-3365-6562)
- Justine Dell’Aringa
- Lara Stepan
- Leanne Peiser
- Alessandro Crotta
- Veronika Bachanová (ORCID: https://orcid.org/0000-0002-9325-432X)
- David M. Kurtz (ORCID: https://orcid.org/0000-0002-6382-4651)
- Abood Okal
- Jacob J. Chabon (ORCID: https://orcid.org/0000-0003-1820-9737)
- Patrick B. Johnston (ORCID: https://orcid.org/0000-0002-3212-3510)
- Sahar Ansari (ORCID: https://orcid.org/0000-0001-7965-0927)
- Victor A. Chow
- Jeremy Abramson
- Bertram Glaß (ORCID: https://orcid.org/0009-0000-0816-688X)
- Francisco Hernandez-Ilizaliturri
- Ethan G. Thompson
- Stephan Mielke (ORCID: https://orcid.org/0000-0002-8325-9215)
- Jon Arnason
Institutions
- Northside Hospital (US)
- Roswell Park Comprehensive Cancer Center (US)
- University of Minnesota (US)
- Beth Israel Deaconess Medical Center (US)
- Karolinska University Hospital (SE)
- Harvard University (US)
- Palo Alto University (US)
- California Institute for Regenerative Medicine (US)
- University of Washington (US)
- Erasmus MC (NL)
- Institute for Stem Cell Biology and Regenerative Medicine (IN)
- Massachusetts General Hospital (US)
- Fred Hutch Cancer Center (US)
- Bristol-Myers Squibb (United States) (US)
- Mayo Clinic in Arizona (US)
- Oklahoma State University Oklahoma City (US)
- University of Colorado Cancer Center (US)
- Foresight Science & Technology (United States) (US)
- Helios Hospital Berlin-Buch (DE)
- Tokyo National Hospital (JP)
- Bristol-Myers Squibb (Switzerland) (CH)
- University of Oklahoma (US)
- University of Colorado Denver (US)
- Stanford University (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1200/jco-25-03051
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00