Rapid Microwave‐Assisted Iodination of Glycals to 2‐Iodoglycals Under Operationally Simple Conditions: Next Chapter in (C‐2)‐Functionalisation of Sugar Moieties

Herein, we report an improved, microwave‐assisted protocol towards 2‐iodoglycals. The procedure itself is efficient, easy to reproduce and might be transferred onto challenging examples of glycals, such as trisaccharide derivatives or analogues of antidiabetic acarbose allowing the synthesis of their 2‐iodoanalogues in few minutes.

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Publication Details

Journal
Chemistry - Methods
Published
2026-04-26
DOI
https://doi.org/10.1002/cmtd.70113
Primary Topic
Carbohydrate Chemistry and Synthesis
Type
article
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article

Rapid Microwave‐Assisted Iodination of Glycals to 2‐Iodoglycals Under Operationally Simple Conditions: Next Chapter in (C‐2)‐Functionalisation of Sugar Moieties

Morgane de Robichon, Dariusz Baran, Andrzej Plichta, Maciej Malinowski et al.
Chemistry - Methods
Carbohydrate Chemistry and Synthesis
article

Rapid Microwave‐Assisted Iodination of Glycals to 2‐Iodoglycals Under Operationally Simple Conditions: Next Chapter in (C‐2)‐Functionalisation of Sugar Moieties

Morgane de Robichon, Dariusz Baran, Andrzej Plichta, Maciej Malinowski, Karolina Hurej, Bartłomiej Stankiewicz, Aneta Pobudkowska, Angélique Ferry, Agnieszka Ewa Kuklewska
article en

Abstract

Herein, we report an improved, microwave‐assisted protocol towards 2‐iodoglycals. The procedure itself is efficient, easy to reproduce and might be transferred onto challenging examples of glycals, such as trisaccharide derivatives or analogues of antidiabetic acarbose allowing the synthesis of their 2‐iodoanalogues in few minutes.

Chemistry - MethodsVol. 6(5)
Warsaw University of Technology (PL), Wrocław University of Science and Technology (PL), Centre National de la Recherche Scientifique (FR), Institut Universitaire de France (FR), University of Wrocław (PL), Université Paris-Saclay (FR), Institut Galien Paris-Saclay (FR), Laboratoire d'Énergétique Moléculaire et Macroscopique, Combustion (FR), Wroclaw University of Health and Sport Sciences (PL), CY Cergy Paris Université (FR), DSW University of Lower Silesia (PL)
Openalex Percentile: Top 8%
Carbohydrate Chemistry and Synthesis
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