The Changing Face of Gastrointestinal Cancer Mortality: Trends and Divide by Age and Geography

Risk-adjusted gastrointestinal (GI) cancer mortality varies by cancer type, age, time, and geography.Early-onset cancer (age < 50 years) is increasing for several cancers, particularly colorectal, breast, and thyroid cancers, and may reflect hereditary, lifestyle, and environmental factors.Early detection through symptom awareness, family history assessment, and timely screening or genetic testing may improve outcomes.This study examined U.S. age-adjusted GI cancer mortality trends by age group (age 20-49 vs. 50 years) and described cancer-specific temporal and geographic patterns.