<scp>5D</scp> Flow <scp>MRI</scp> Reveals Respiration‐Driven Changes in Blood Flow Energetics in Congenital Heart Disease

PURPOSE: Hemodynamic monitoring is essential for patients with right-sided congenital heart disease (CHD). Respiration may have an increased impact on pulmonary flow in these patients that cannot be assessed by standard tools including 4D flow MRI. This study uses 5D flow MRI to assess respiratory-cycle variations in flow energetics in patients with CHD. METHODS: ) as a measure of flow inefficiency were calculated in inferior and superior caval veins (IVC, SVC), pulmonary arteries (PA), and aorta. Correlations were assessed with clinical markers of altered cardiac flow function. RESULTS: was associated with increased Fontan left-right PA flow differential (ρ = -0.68, p < 0.05) and increased shunt Qp/Qs (ρ = -0.70, p < 0.05). CONCLUSIONS: The findings of this study show that CHD flow energetics and efficiency are modulated by respiration. Respiratory-resolved imaging is needed to identify these dynamics and their relationships to overall cardiac function.