Bayesian Analysis of Postoperative Complication Risk Associated With Preoperative Exposure to Fine Particulate Matter: A Single‐Center Cohort Study
BACKGROUND: ) exposure and postoperative complications, highlighting its interpretability and flexibility for clinical environmental epidemiology. METHODS: concentrations in the 7 days prior to surgery. The binary outcome was a composite of postoperative complications: pneumonia, surgical site infection, urinary tract infection, sepsis, stroke, myocardial infarction, or thromboembolic event. A hierarchical Bayesians regression model with weakly informative priors was used adjusting for age, sex, season, neighborhood disadvantage, and the Elixhauser index of comorbidities with census tract as a group (random) effect. We present posterior estimates with credible intervals, highlight model transparency and sensitivity, and discuss contrasts with standard frequentist methods. RESULTS: , the odds of complication rose to over 27% (95% CI: 4%-55%). The results were robust across prior choices and model specifications. We report full posterior distributions and highlight advantages of Bayesian modeling for uncertainty quantification and clinical interpretability. CONCLUSIONS: exposure and postoperative complications, highlighting transparent risk estimation and uncertainty characterization that may inform the design of future multicenter perioperative environmental studies. EDITORIAL COMMENT: Using Bayesian statistical analysis, the authors demonstrate a dose-dependent risk for postoperative complications in patients exposed to air polluted with fine particulate matter with a size of less than 2.5 μm.
Authors
- Cameron K. Jacobson
- Neng Wan (ORCID: https://orcid.org/0000-0001-8214-9164)
- Nathan L. Pace (ORCID: https://orcid.org/0000-0002-8646-5276)
- Tabitha M. Benney (ORCID: https://orcid.org/0000-0001-5800-8919)
- John F. Pearson (ORCID: https://orcid.org/0000-0001-5607-4517)
- Matthew J. Strickland (ORCID: https://orcid.org/0000-0003-3027-5470)
- Calvin S. Riss
- Cade K. Kartchner
- Longyin Lee
- Jacob A. Wood
- Ben K. Goodrich
- Jonah S. Gabry
- Michael H. Andreae
- John V. Pham
Institutions
- University of Nevada, Reno (US)
- City University of New York (US)
- University of Utah (US)
- Columbia University Irving Medical Center (US)
- Sustainability Institute (ZA)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Columbia University (US)
- Stanford University (US)
Publication Details
- Journal
- Acta Anaesthesiologica Scandinavica
- Published
- 2026-04-26
- DOI
- https://doi.org/10.1111/aas.70235
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- National Cancer Institute
- National Institute of Environmental Health Sciences